负责人：张林、周斌、王霞

PI：Lin Zhang

Co-PI：Bin Zhou 、Xia Wang

分子与转化医学实验室发挥基础研究与临床实际紧密结合的优势，主要致力于疾病的基础与转化研究。实验室研究方向主要为以下几方面：针对肿瘤、心血管疾病等进行致病基因、疾病相关基因的定位、克隆；利用细胞，动物模型及临床标本为研究材料，通过研究细胞内信号传导通路在疾病发生发展中的变化和作用，从分子，细胞到个体水平研究疾病的机理；从细胞内信号传导通路入手，研究恶性肿瘤的发病机理和耐药机理，探寻可用于恶性肿瘤预防、诊断和治疗的生物标志物和新策略，筛选新的天然及合成抗癌药物并研究其抗癌机理；妊娠期常见疾病和肾脏疾病的标志物筛查及机制研究；非编码RNA启动子区遗传变异和环状RNA在肿瘤发病中的作用研究。

Takingadvantage of scientific and clinical resources at The Laboratory of Molecularand Translational Medicine and West China Second University Hospital, our Labfocus on the basic and translational research of commonly encountered diseasesin our hospital. The following are the main fields of our research. Locate andclone genes associated with cancer and cardiovascular disease. Explore themolecular and cellular mechanisms involved in pathogenesis of diseases throughinvestigation of cellular signal transduction by using cells, animal models,and clinic samples as study ob-x-ject. Study the mechanisms underlying carcinogenesisand chemoresistance in malignant neoplasms, and explore biomarkers and newstrategy in the prevention, diagnosis, and treatment of cancer. Screen newanti-tumor drugs from natural occurring compounds and total synthesizedcompounds and elucidate the molecular mechanisms involved. Screen biomarkers ofdiseases in pregnancy and kidney disease and investigate the mechanism of thosediseases. Investigate the role of genetic variants in the promoter region ofnon-coding RNA and circular RNAs on tumorigenesis.