简介

1.职称：研究员

2.学历：博士

3.研究方向：器官再生和修复；组织纤维化

4.邮件：dingbisen@scu.edu.cn

5.教育经历：南京大学学士，硕士，宾夕法尼亚大学博士，康奈尔大学博士后，助理教授  

6.主要获奖情况

2013年 纽约科学院Blavatnik青年科学家奖

7.发表论文

(1). Cao Z*, Lis R, Ginsburg M, Chavez D, Shido K, Rabbany SY, Fong GH, Sakmar TP, Rafii S*, Ding BS*. Targeting of pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nature Medicine 2016, 22(2):154-62 (Journal Cover) (*Corresponding author). PMID 26779814

Highlighted in 1) Science Signaling 2016, 9(415):ec31; 2) Nature Review of Drug Discovery 2016, 2016 Feb 26. doi: 10.1038/nrd.2016.25.

(2). Rafii S*, Butler JM*, Ding BS*. Angiocrine functions of organ-specific endothelial cells Nature 2016, 529(7586):316-25. (*Corresponding author). PMID 26791722

(3). Rafii S, Cao Z, Lis R, Chavez D, Shido K, Rabbany SY, Ding BS*. Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Nature Cell Biology 2015, 17(2):123-36. (*Corresponding author). PMID 25621952.

(4). Ding BS*, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold M, Shido K, Rabbany SY, and Rafii, S*. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature 2014, 505(7481):97-102. (ePub 2013 Nov 20) (* Corresponding author).   PMID 24256728

Highlighted in 1) Science Signaling 2014, 7(307):ec7; 2) F1000 Prime (article 718183961); 3) Science Translational Medicine 2014, 6(224):ec33. 4) Hepatology 2014, doi:10.1002 /hep.27116.

(5). Cao Z, Ding BS*, Guo P, Lee SL, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Scandura JM, Rafii, S*. Angiocrine signals from tumor vascular niche induce B-Cell lymphoma invasiveness and chemoresistance. Cancer Cell 2014, 25(3): 1-16. (* Corresponding author). PMID 24651014

Highlighted in 1) Cancer Cell 2014, 25 (3), 261–263; 2) Nature Reviews Cancer 14, 298 (2014) doi:10.1038/nrc3730; 3)  Science Signaling 2014, 7 (319): p. ec85.

(6). Ding BS, Nolan DJ, Guo P, Babazadeh AO, Cao Z, Rosenwaks Z, Sato TN, Shido K, Rabbany SY, Rafii S. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 2011, 147:539-553.  PMID 22036563        

Highlighted in Cell 2011, 147(3):485-7.

(7). Ding BS, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, Sato TN, Rabbany SY, & Rafii S. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 2010; 468(7321):310-5. PMID 21068842

Highlighted in 1) Journal of Hepatology 2011, 55(2):488-90; 2) Hepatology 2011;54(2):731-3. 3) Faculty of 1000 Biology (article 6577956).

(8). Ding BS, Gomi K, Rafii S, Crystal RG, Walters MS. Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J. Cell Sci. 2015 Aug 15;128(16):2983-8. PMID 26116571

(9). Ding BS, James D, Iyer R, Falciatori I, Hambardzumyan D, Wang S, Butler JM, Rabbany SY, Hormigo A. Prominin 1/CD133 endothelium sustains growth of proneural glioma. PLoS One. 2013 Apr 25;8(4):e62150. PMID 23637986

(10). Curradi G#, Walters MS#, Ding BS#, Rafii S, Hackett NR, Crystal R. Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells. Cellular and Molecular Life Sciences 2012 (ePub) (#contributed equally). PMID 22382924

(11). Ding BS, Hong N, Christofidou-Solomidou M, Gottstein C, Albelda SM, Cines DB, Fisher AB, Muzykantov VR. Anchoring Fusion thrombomodulin to the Endothelial Lumen Protects Injury-Induced Lung Thrombosis and Inflammation. American Journal of Respiratory and Critical Care Medicine 2009;180(3):247-56. PMID 19342415

(12). Ding BS, Hong N, Murciano JC, Ganguly K, Gottstein C, Christofidou-Solomidou M, Albelda SM, Fisher AB, Cines DB, Muzykantov VR. Prophylactic thrombolysis by thrombin-activated latent pro-urokinase targeted to PECAM-1 in the pulmonary vasculature. Blood 2008; 111(4):1999-2006. PMID 18045968

(13). Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. Advanced drug delivery systems that target the vascular system. Molecular Intervention 2006; 6: 98-112. PMID 16565472

(14). Ding BS, Gottstein C, Grunow A, Kuo A, Ganguly K, Albelda SM, Cines DB, Muzykantov VR. Endothelial targeting of a recombinant construct fusing a PECAM-1 scFv with pro-urokinase facilitates prophylactic thrombolysis in the pulmonary vasculature. Blood 2005; 106: 4191-4198. PMID 16144802

(15). Ding BS, Zhou YJ, Chen XY, Zhang J, Zhang PX, Tan XY, Liu JN. Lung Endothelium Targeting for Pulmonary Embolism Thrombolysis. Circulation (Rapid Track) 2003; 108: 2892-2898. PMID 14610017